Famotidine is what is known as an H2-blocker. It works by blocking a receptor in the stomach that triggers the release of acid. Famotidine has been shown to be both safe and effective at suppressing acid levels in the stomach and improving the symptoms of GERD.
Gaviscon is an over-the-counter medication that is effective in the treatment of GERD symptoms.The main ingredient, sodium alginate, is derived from seaweed. Once ingested, the seaweed makes a gel-like layer that sits at the top of the stomach and blocks stomach contents from refluxing back up into the esophagus. Gaviscon also contains two antacids, calcium carbonate, and sodium bicarbonate, which help to reduce acidity in the stomach.
Proton pump inhibitors are powerful acid-suppressing medications that work by inhibiting the proton pumps in the stomach that control the release of acid. These medications can be used temporarily to treat more severe symptoms of GERD, allowing for control of symptoms while lifestyle modifications and other treatments are being tried.
PPIs should be used for the shortest duration possible and your provider may help try to slowly wean you off of this medication. However, there are some people who may need to stay on PPIs long-term. This includes people who have had damage to the lining of the esophagus and have been able to heal while on a PPI, and also those with a condition that causes excess white blood cells in the esophagus called eosinophilic esophagitis. PPIs can also prevent the progression of a condition called Barrett’s esophagus and can be used for the prevention of ulcers for people with significant risk factors.
Dietary fiber acts on the gastrointestinal tract by bulking up the stool, improving the movement of gut contents through the intestine, promoting beneficial bacteria, and even by regulating the immune and neuroendocrine systems. Soluble fiber has been shown to improve symptoms of GERD, likely due to improving the movement of food out of the stomach and reducing pressure on the lower esophageal sphincter.
Gamma-oryzanol is a component of rice bran oil known for its antioxidant capabilities. Reduction of gastric acid and protection from stomach ulcers has been shown in animal models, but more research is needed to determine if the same effect is seen in humans.1 Nevertheless, this is a food-based supplement that is generally thought to be very safe.
Licorice root may improve GERD symptoms by decreasing inflammation and increasing protective mucus to line the digestive tract and esophagus.1 When used long term, it is important to use only the deglycyrrhizinated version—prolonged use of the unprocessed, dried root can cause elevated blood pressure, swelling, and unsafe drops in potassium.
Slippery elm is a tree that is native to North America and has been used as a home remedy for centuries. The inner bark becomes viscous in contact with water and forms a protective coating. Slippery elm is often blended with other herbs for use in common gastrointestinal conditions.2
Similar to slippery elm, marshmallow is thought to help form a protective coating in addition to its antioxidant effects.1 More research is needed to determine its efficacy in the treatment of GERD symptoms, but it is generally regarded as safe by the FDA.
Artichoke is a plant grown in the Mediterranean region of Southern Europe and Northern Africa. Artichokes can be consumed as a food and extracts of the leaves are used medicinally. Artichoke works in the gastrointestinal tract to stimulate the flow of bile and as an antispasmodic. It has been shown to relieve discomfort and nausea after meals.
Turmeric is a brightly colored spice commonly used in Asian foods and widely known for its anti-inflammatory properties. Turmeric may improve gastrointestinal symptoms by lowering inflammation, increasing the release of digestive enzymes, and promoting gut motility.1
The body naturally makes proteins called digestive enzymes which help to break down and digest food. Supplement versions of these naturally occurring enzymes come from plants and animals. More research is needed to determine whether supplemental enzymes taken to aid in digestion can reduce symptoms of GERD.
It is becoming increasingly clear that the microbiome plays an important role in the development of GI conditions.Probiotics, or “good bacteria” may be a useful tool in the treatment of GERD. Studies show that supplementation with probiotics improves some of the most common symptoms including heartburn and regurgitation.2