What is MASLD & MASH?
After receiving a new diagnosis, the most common thought to cross your mind is probably "What caused this?" However, when it comes to MASLD, there is rarely a single answer to this question as many factors are likely at play. Some factors that contribute to the development of metabolic liver disease include:
Obesity
Excess body weight, particularly abdominal obesity, is a significant risk factor for MASLD and MASH. The good news is that even a modest weight loss of 3-5% can improve the amount of fat stored in the liver.1
Insulin Resistance
Insulin resistance occurs when your cells become less responsive to insulin. Normally, insulin sends signals telling your cells to let in glucose to be used for energy and to stop breaking down fats for energy. With insulin resistance, the cells start ignoring this signal, eventually leading to uncontrolled blood sugars and excess fatty acids in the bloodstream, which are then stored and accumulate in the liver, where they lead to the development of MASLD.2
Genetics
Genetic factors may predispose some individuals to MASLD and MASH, as specific genetic mutations can affect how fat is processed and stored in the liver.1
Diet
High intake of sugar, refined carbohydrates, and saturated fats has been shown to contribute to the development of MASLD, as these foods can cause increased fat deposition in the liver.3
Sedentary Lifestyle
Inadequate physical activity is associated with obesity and insulin resistance, risk factors for MASLD and MASH. Exercise, even without accompanying weight loss, may improve fat composition in the liver.1
Gut Microbiota
The microbiome is a group of trillions of microorganisms—including bacteria, fungi, and viruses—that live in the gut. Emerging research suggests that an imbalance in gut bacteria (dysbiosis) may play a role in developing MASLD and MASH.4
Sleep Apnea
Individuals with sleep apnea, characterized by interrupted breathing during sleep, are at a higher risk of developing MASLD.5
The good news is that, except for genetics, most root causes for MASLD can be addressed with lifestyle. Small changes in nutrition, movement, sleep, etc., can go a long way in the treatment of MASLD and in the prevention of progression. As you progress on your health journey, your Salvo Health team will be there to help you identify these small changes you can make in your own life and build a personalized care plan that works for you.
*References available with PDF download*